Nortriptyline Pharmacogenetics and postural hypotension
2008 Research Project Grant Round
Approved for Funding by CMRF $42,604.00
For a period of 7 months
Start Date: 01 March 2009
Reseacher 1: Dr Berit Jensen
University of Otago, Christchurch
Photo: Blood pressure is being monitored
using a tilt table
From left: Berit Jensen, Professor Evan Begg, Rebecca Roberts
Reseacher 2: Dr Rebecca Roberts
University of Otago, Christchurch
Reseacher 3: Dr Evan J Begg
University of Otago, Christchurch
Antidepressants – Do genes alter the risk of developing adverse effects?
Nortriptyline is a drug taken by many patients to treat depression. A common
side effect is ‘postural hypotension’, a decrease in blood pressure which
happens when changing from a lying or seated position to standing.
This can result in dizziness or even fainting. This study looks at a
possible genetic reason for some people to be particularly
sensitive to this adverse effect. Healthy volunteers are invited to
participate in the study and are given one dose of nortriptyline.
Blood pressure is monitored while the volunteer is ‘tilted’ using a
special table, and blood samples are taken.
Volunteers interested in participating are welcome to contact us on
03 364 640 ext. 89671 or ext. 88642.