Polymorphic variants of X-linked genes in heart disease
2007 Research Project Grant Round
Approved for funding by CMRF
AMOUNT FUNDED: $66,983.00
for a 12 month period
Researcher 1: Dr Barry Palmer
University of Otago, Christchurch
Photo shows Barry Palmer in the laboratory
Researcher 1 - Dr Barry Palmer
University of Otago, Christchurch
Researcher 2 - Associate Professor Vicky Cameron
University of Otago, Christchurch
Researcher 3 - Professor Mark Richards
University of Otago, Christchurch
Specific Objective(s)/Aims for this research.
1. Genotype DNA samples from the Post-myocardial infarction (PMI), Heart-Healthy Volunteer (HV) & Acute Coronary Syndromes (ACS) cohorts for polymorphisms representing the major genetic variants of the ACE2, AT2R & KCNE5 genes.
2. Analyse genotype/haplotype data for associations with baseline characteristics, neurohormonal profiles, cardiac function, initial risk of acute MI and ACS and clinical outcome after acute events.
The study will evaluate whether polymorphisms in these genes contribute to the greater incidence of heart disease in male patients and if females with two copies of the same gene variants have poorer clinical outcome after disease events than those with two different variants of these genes. The ultimate outcome of this and related research is a panel of genetic tests that can be used in compiling patient risk profiles and individual treatment regimes.
